Department Seminar

Upcoming Seminar

Multiomics Systems Biology of Complex Diseases
Dr. Xia Yang, UCLA

April 30, 2025
4:00pm-5:00pm in HSCI-105

Xia Yang

Common complex diseases such as cardiovascular disease, diabetes, and Alzheimer’s disease are the result of interactions between genetic and environmental risks factors and involve network perturbations across molecular entities, cell types, tissues, and organ systems. Dissecting such complexity necessitates a multitissue multiomics approach that integrates bulk and single cell multiomics data (genome, epigenome, transcriptome, proteome, metabolome, gut microbiome) across relevant tissues and cell types. I will delineate the conceptual framework underlying our recent method development efforts that enable causal network modeling of multiomics data, and showcase application examples of such approaches in mechanistic and drug discovery in biomedicine.

diseases and gene networks
Fig.: Complex diseases are the result of causal risks (genetics or environmental) that affect tissue functions by perturbing multiomics molecular entities that interact in tissue-specific gene networks. Multitissue multiomics systems biology aims to identify the gene subnetworks in multiple tissues (depicted in dotted circles), relevant to a particular complex disease, that are influenced by genetic and/or environmental risks. A molecular network is comprised of nodes representing molecular entities, such as genes or proteins, and edges that connect the nodes. Network hubs (red nodes) have more connections than peripheral nodes (white nodes) and likely play more important roles in disease etiology.

Seminars are held on Wednesdays at 4:00pm. All are invited to attend.

Seminar Coordinator

For information and suggestions about our Department Seminar series, please contact the seminar coordinator:

Dr. Fangyuan Tian
Fangyuan.Tian@csulb.edu

Schedule

The following schedule is for Spring 2025.

Seminar Schedule
DateTitleSpeaker and Affiliation
April 30, 2025TBADr. Xia Yang, UCLA
May 7, 2025Moiré excitons in van der Waals MaterialsDr. Gang Lu, CSU Northridge

Previous Seminars

Previous Spring 2025 Seminars
DateTitleSpeaker and Affiliation
April 23, 2025Solution-Phase Routes to Inorganic Solid-State MaterialsDr. Alina Schimpf, UC San Diego
April 16, 2025Part 1: Some Studies with Chiral Compounds and Stereoselection;
Part 2: Organophosphorus Compounds as Butyrylcholinesterase Inhibitors		Dr. Ken Nakayama, CSU Long Beach
April 9, 2025Fundamental Studies of Microporous Polymers and their Applications in BiomedicineDr. James Bour, Wayne State University
March 19, 2025Defining the Pathways of Eukaryotic Translational Quality ControlDr. Michael Lawson, UCLA
March 12, 2025Intra and extracellular mechanisms regulating AMPA receptor trafficking and synaptic dockingDr. Javier Diaz Alonso, UC Irvine
March 5, 2025Chemical Approaches to Perturb and Illuminate Biological ProcessesDr. Chao Zhang, USC
February 26, 2025Chemical and Physical Properties of Independence Day Fireworks Aerosol Particle Emissions in Southern CaliforniaDr. Daniel Curtis, CSU Fullerton
February 19, 2025Single molecule investigation of liquid-liquid and liquid-solid phase separation of amyloid proteinsDr. Kanchan Garai, Tata Institute of Fundamental Research, Hyderabad, India
February 12, 2025Bio-Integrated Nanoelectronics for Precision Medicine and BiomanufacturingDr. Deependra Ban, UC San Diego
February 5, 2025Dynamically Tunable Plasmonic Surfaces using Oscillatory Electric FieldsDr. Regina Ragan, UC Irvine
January 29, 2025Beginning to understand light-mediated Ni catalysis using physical organic techniques and data scienceDr. Ana Bahamonde, UC Riverside

The Seminar Archive has Department Seminars from previous semesters.

The Department Seminar is supported by The Allergan Foundation.